Endocrine Abstracts

Although it is becoming increasingly clear that testosterone exerts an inhibitory influence on stress-induced adrenocorticotropin (ACTH) and corticosterone release, where and how this occurs in the brain remains poorly understood. We previously determined that androgen receptors are not distributed within anterior pituitary communicating neurons of the paraventricular nucleus (PVN) of the hypothalamus (Bingham et al. J Comp Neurol 2006). However, they are contained with...

Isochromosome Mosaic Turner Syndrome (IMTS) is a variant of Turner Syndrome (TS) characterized by cytogenetic profile of 1 or more additional cell lineages aside from 45,X, and the presence of a structurally abnormal X chromosome consisting of either two short or two long arms. IMTS is rare, with only 8–9% prevalence among women with TS based on international studies, and 15% of all TS in the Philippines. A 20 year old female came in due to amenorrhea and alopecia. Physic...

Case history: We report a 38 year-old Caucasian woman with classical salt wasting congenital adrenal hyperplasia (CAH) who increasingly omitted medication in adolescence and eventually spent over 10 years without any adrenal replacement therapy or adrenal crises and became lost to follow up. When seen, she complained of increasing abdominal girth, fatigue, hirsutism, had type 2 diabetes, had never had a romantic/sexual relationship and was amenorrhoeic. Examination revealed ab...

Introduction: Cardiac paragangliomas are rare endocrine neoplasms. Surgical resection is first line treatment. Here, we describe a case of cardiac paraganglioma where surgical resection was aborted due to involvement of important cardiac structures. Systemic therapy was instead pursued with tyrosine kinase inhibitor cabozantinib.Case: A 64-year-old man with a past medical history significant for tobacco use and poorly controlled type 2 diabetes mellitus ...

Introduction: Obesity is nowadays one of the most important challenges in public health and, therefore, the investigation of their causes is most relevant. Among the various behavioral roots of obesity, the emotional over ingestion determined by emotional factors, i.e. emotional eating (EE), is one of them.Objectives: To study how emotions contribute to obesity in woman.Methods: We gathered a convenience sample 220 woman in the hos...

Background: Vitamin B12 (B12) is an essential micronutrient required for optimal hematopoietic, neurologic and other several metabolic reactions. Longitudinal studies and animal models showed that low maternal vitamin B12 deficiency is associated with the maternal obesity, development of insulin resistance and metabolic syndrome phenotype. Although the mechanisms underpinning metabolic disorders remain poorly defined, it has become increasingly cle...

Background: Vitamin B12 (B12) is an essential micronutrient required for optimal hematopoietic, neurologic and other several metabolic reactions. Longitudinal studies and animal models showed that low maternal vitamin B12 deficiency is associated with the maternal obesity, development of insulin resistance and metabolic syndrome phenotype. Although the mechanisms underpinning metabolic disorders remain poorly defined, it has become increasingly cle...

Thyroid hormones (THs) play a crucial role orchestrating neurodevelopment, but also regulate adult brain function. Recently, the potent effects that THs exert in adult neurogenic niches have started to be uncovered in rodents. These include an important role in the modulation of progenitor generation, especially controlling whether a neural stem cell (NSC) determines to become a neuronal or an oligodendroglial progenitor in the adult subventricular zone (SVZ), the largest NSC ...

Introduction: Non-alcoholic fatty-liver disease and T2DM remain a global burden. Metformin is the first-line drug for T2DM that decreases glucose and lipid levels. However, prolonged metformin treatment decreases vitamin B12(B12), whereas low B12 is associated with obesity and dyslipidaemia. Clinical studies showed that metformin treatment increases circulating adiponectin and adiponectin improves NAFLD. Others suggested that metformin has no effect on intrahepatic triglycerid...

To analyze the data of relatives of first-degree patients operated on for medullary thyroid cancer (MTC), we analyzed the anamnestic data of the database of patients with MTC, formed on the basis of the cancer registry of the Republic of Belarus and medical records of the Republican Thyroid Tumor Center. Further examination of relatives is also performed on the basis of the Republican Center for Thyroid Tumors.The aim: of the study was to create a databa...